Marine Drugs (Oct 2018)

Components from the Leaves and Twigs of Mangrove <i>Lumnitzera racemosa</i> with Anti-Angiogenic and Anti-Inflammatory Effects

  • Szu-Yin Yu,
  • Shih-Wei Wang,
  • Tsong-Long Hwang,
  • Bai-Luh Wei,
  • Chien-Jung Su,
  • Fang-Rong Chang,
  • Yuan-Bin Cheng

DOI
https://doi.org/10.3390/md16110404
Journal volume & issue
Vol. 16, no. 11
p. 404

Abstract

Read online

One new neolignan, racelactone A (1), together with seven known compounds (2−8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC50 values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 μM, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed.

Keywords