Intensifity of Lipid Peroxidation and Antioxidant Status at Patients with Different Types of Cardiovascular Disease

Abstract

Purpose: The estimation of lipid peroxidation and antioxidant status at patients with acute form of myocardial infarction and postinfarction cardiosclerosis.Materials and Methods: Erythrocytes and plasma of venous blood were taken from 200 patients.Results: It was established that acute course of myocardial infarction characterized by intensification of lipid peroxidation. On our opinion, the hyperproduction of hydrogen peroxide is leading mechanism in vessel tense regulation. Tissue hypoxia was found at postinfarction cardiosclerosis, we suppose that it activates the tissue macrophages and stimulates the synthesis of intercellular matrix components.Summary: the orientation and degree of manifestation of activity changes of plasma and erythrocytic superoxide dismutase can serve as prognostic criterion of myocardial infarction.

Keywords

• lipid peroxidation
• antioxidant status
• myocardial infarction