Malignant melanoma and basal cell carcinoma detection with 457 nm laser-induced fluorescence

Abstract

In this study we propose a several methods of autofluorescence signal processing for skin cancers control. Autofluorescence spectra of normal skin and oncological pathologies stimulated by 457 nm laser were registered for 56 skin tissue samples. Spectra of 9 melanomas and 19 basal cell carcinomas were registered ex vivo. Estimation of tissue malignancy was made on the basis of autofluorescence spectra intensity and shifts of local maxima in 570 – 590 nm and 610 – 670 nm area. Separation of melanomas and basal cell carcinomas was performed with linear discriminant analysis. Overall accuracy of tissue type determining in current study reached 82.1%.

Keywords

• autofluorescence
• spectroscopy
• cancer detection
• malignant melanoma
• basal cell carcinoma
• discriminant analysis