The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

F. Windler; W. Bönigk; H. G. Körschen; E. Grahn; T. Strünker; R. Seifert; U. B. Kaupp

doi:10.1038/s41467-018-05253-x

Nature Communications (Jul 2018)

The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

F. Windler,
W. Bönigk,
H. G. Körschen,
E. Grahn,
T. Strünker,
R. Seifert,
U. B. Kaupp

Affiliations

F. Windler: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
W. Bönigk: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
H. G. Körschen: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
E. Grahn: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
T. Strünker: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
R. Seifert: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems
U. B. Kaupp: Center of Advanced European Studies and Research (caesar), Department Molecular Sensory Systems

DOI: https://doi.org/10.1038/s41467-018-05253-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The sperm-specific solute carrier SLC9C1 is a phylogenetic chimaera that carries a voltage-sensing (VSD) and a cyclic nucleotide-binding domain (CNBD). Here authors show by electrophysiology and fluorimetry that SLC9C1 is a genuine Na+/H+ exchanger gated by voltage and cAMP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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