Acoustic tweezer-driven assembly and anti-cancer property of microporous magnesium gallate

Abstract

The study focuses on fabrication and characterization of magnesium gallate (Mg-Gal), and introduces the use of single beam acoustic tweezers for aggregation and manipulation of Mg-Gal. Initially, microparticles are fabricated and thoroughly characterized, revealing their crystalline nature and thermostability stability. Through techniques like X-ray Diffraction (XRD), Fourier Transform-Infrared (FT-IR) spectroscopy, and electron microscopy, the structural and compositional features are elucidated. Subsequently, we intended to explore the effect of acoustic tweezer which are upcoming technology that possess multiple biological applications like drug delivery, cell analysis and tissue engineering. We demonstrated a successful aggregation and manipulation of these microparticles using a single beam acoustic tweezer system equipped with 7.5 MHz transducer. Within a short duration of 12 s, aggregates of around 100 μm size are formed and manipulated within the field of vision. Additionally, the anti-cancer potential of Mg-Gal microparticles was investigated in vitro, displaying significant cytotoxicity and anti-proliferative activity against MDA-MB-231 cells, with an IC50 value of 79.18 μg/ml. The study emphasizes the promising prospects of Mg-Gal microparticles in targeted drug delivery using ultrasound for cancer treatment and underscores the material's potential for conjugation with therapeutic drugs to address various complex diseases. Overall, this research highlights the interdisciplinary approach in advancing both material manipulation techniques and biomedical applications.

Keywords

• Magnesium
• Gallic acid
• Metal-organic framework
• Acoustic tweezers
• Ultrasound