Crystal structure of NOD2 and its implications in human disease

Sakiko Maekawa; Umeharu Ohto; Takuma Shibata; Kensuke Miyake; Toshiyuki Shimizu

doi:10.1038/ncomms11813

Nature Communications (Jun 2016)

Crystal structure of NOD2 and its implications in human disease

Sakiko Maekawa,
Umeharu Ohto,
Takuma Shibata,
Kensuke Miyake,
Toshiyuki Shimizu

Affiliations

Sakiko Maekawa: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Umeharu Ohto: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Takuma Shibata: Department of Microbiology and Immunology, Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo
Kensuke Miyake: Department of Microbiology and Immunology, Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo
Toshiyuki Shimizu: Graduate School of Pharmaceutical Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms11813
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mechanism for autoinhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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