PLoS ONE (Jan 2022)
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
- Sandra Martín-Peláez,
- Lluis Serra-Majem,
- Naomi Cano-Ibáñez,
- Miguel Ángel Martínez-González,
- Jordi Salas-Salvadó,
- Dolores Corella,
- Camille Lassale,
- Jose Alfredo Martínez,
- Ángel M. Alonso-Gómez,
- Julia Wärnberg,
- Jesús Vioque,
- Dora Romaguera,
- José López-Miranda,
- Ramón Estruch,
- Francisco J. Tinahones,
- José Lapetra,
- Fernando Fernández-Aranda,
- Aurora Bueno-Cavanillas,
- Josep A. Tur,
- Vicente Martín,
- Xavier Pintó,
- Miguel Delgado-Rodríguez,
- Pilar Matía,
- Josep Vidal,
- Clotilde Vázquez,
- Lidia Daimiel,
- Emili Ros,
- Estefanía Toledo,
- Stephanie K. Nishi,
- Jose V. Sorli,
- Mireia Malcampo,
- M. Ángeles Zulet,
- Anaí Moreno-Rodríguez,
- Raquel Cueto-Galán,
- Diego Vivancos-Aparicio,
- Antoni Colom,
- Antonio García-Ríos,
- Rosa Casas,
- M Rosa Bernal-López,
- Jose Manuel Santos-Lozano,
- Zenaida Vázquez,
- Carlos Gómez-Martínez,
- Carolina Ortega-Azorín,
- Jose Luís del Val,
- Itziar Abete,
- Amaia Goikoetxea-Bahon,
- Elena Pascual,
- Nerea Becerra-Tomás,
- Juan J. Chillarón,
- Almudena Sánchez-Villegas
Affiliations
- Sandra Martín-Peláez
- Lluis Serra-Majem
- Naomi Cano-Ibáñez
- Miguel Ángel Martínez-González
- Jordi Salas-Salvadó
- Dolores Corella
- Camille Lassale
- Jose Alfredo Martínez
- Ángel M. Alonso-Gómez
- Julia Wärnberg
- Jesús Vioque
- Dora Romaguera
- José López-Miranda
- Ramón Estruch
- Francisco J. Tinahones
- José Lapetra
- Fernando Fernández-Aranda
- Aurora Bueno-Cavanillas
- Josep A. Tur
- Vicente Martín
- Xavier Pintó
- Miguel Delgado-Rodríguez
- Pilar Matía
- Josep Vidal
- Clotilde Vázquez
- Lidia Daimiel
- Emili Ros
- Estefanía Toledo
- Stephanie K. Nishi
- Jose V. Sorli
- Mireia Malcampo
- M. Ángeles Zulet
- Anaí Moreno-Rodríguez
- Raquel Cueto-Galán
- Diego Vivancos-Aparicio
- Antoni Colom
- Antonio García-Ríos
- Rosa Casas
- M Rosa Bernal-López
- Jose Manuel Santos-Lozano
- Zenaida Vázquez
- Carlos Gómez-Martínez
- Carolina Ortega-Azorín
- Jose Luís del Val
- Itziar Abete
- Amaia Goikoetxea-Bahon
- Elena Pascual
- Nerea Becerra-Tomás
- Juan J. Chillarón
- Almudena Sánchez-Villegas
- Journal volume & issue
-
Vol. 17,
no. 4
Abstract
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55–75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).