Communications Biology (Feb 2023)
Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans
- Dardo Tomasi,
- Peter Manza,
- Jean Logan,
- Ehsan Shokri-Kojori,
- Michele-Vera Yonga,
- Danielle Kroll,
- Dana Feldman,
- Katherine McPherson,
- Catherine Biesecker,
- Evan Dennis,
- Allison Johnson,
- Kai Yuan,
- Wen-Tung Wang,
- John A. Butman,
- Gene-Jack Wang,
- Nora D. Volkow
Affiliations
- Dardo Tomasi
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Peter Manza
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Jean Logan
- Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine
- Ehsan Shokri-Kojori
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Michele-Vera Yonga
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Danielle Kroll
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Dana Feldman
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Katherine McPherson
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Catherine Biesecker
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Evan Dennis
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Allison Johnson
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Kai Yuan
- School of Life Science and Technology, Xidian University
- Wen-Tung Wang
- Radiology and Imaging Sciences, Clinical Center, National Institute of Health
- John A. Butman
- Radiology and Imaging Sciences, Clinical Center, National Institute of Health
- Gene-Jack Wang
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- Nora D. Volkow
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- DOI
- https://doi.org/10.1038/s42003-023-04545-3
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 10
Abstract
Combined PET imaging and mathematical simulations reveal that the rate of dopamine increase in the striatum underlies self-reports of drug “high” in response to oral and intravenous methylphenidate challenges in humans
