Genome-wide chromatin accessibility is restricted by ANP32E

Kristin E. Murphy; Fanju W. Meng; Claire E. Makowski; Patrick J. Murphy

doi:10.1038/s41467-020-18821-x

Nature Communications (Oct 2020)

Genome-wide chromatin accessibility is restricted by ANP32E

Kristin E. Murphy,
Fanju W. Meng,
Claire E. Makowski,
Patrick J. Murphy

Affiliations

Kristin E. Murphy: Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester Medical Center
Fanju W. Meng: Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester Medical Center
Claire E. Makowski: Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester Medical Center
Patrick J. Murphy: Department of Biomedical Genetics, Wilmot Cancer Institute, University of Rochester Medical Center

DOI: https://doi.org/10.1038/s41467-020-18821-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Chromatin state underlies cellular function, and transcription factor binding patterns along with epigenetic marks define chromatin state. Here the authors show that the histone chaperone ANP32E functions through regulation of H2A.Z to restrict genome-wide chromatin accessibility and to inhibit gene transcriptional activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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