Journal of Gandhara Medical and Dental Sciences (Apr 2023)

Effect of Empagliflozin On Liver Enzymes of Patients In Non-Alcoholic Steatohepatitis In Type 2 Diabetes Mellitus

  • Nauman Wazir,
  • Shafqat Ur Rehman,
  • Muhammad Arshad,
  • Muhammad Zubair Wazir,
  • Shehriyar Khan,
  • Muhammad Saqib Ullah

DOI
https://doi.org/10.37762/jgmds.10-2.375
Journal volume & issue
Vol. 10, no. 2

Abstract

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OBJECTIVES To assess the effect of 10 mg and 25 mg once daily Empagliflozin on liver enzymes of patients of non-alcoholic steatohepatitis in patients of type 2 diabetes mellitus (T2DM). METHODOLOGY The study design was Quasi Experimental. Thirty three adult patients of Type 2 diabetes mellitus (T2DM) who were already on 2000 mg of Metformin and 100 mg of Sitagliptin and were having suboptimal glycemic control (HBA1C > 7% 0.05) decrease mean ALT levels in Group A pre-treatment and 12 weeks post-treatment. Similarly, there was a statistically significant (p > 0.05) decrease mean ALT levels in Group B pre-treatment and 12 weeks post-treatment. CONCLUSION Empagliflozin in both 10mg and 25 mg once daily doses cause statistically significant reduction in ALT levels in patients with NASH associated with T2DM

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