Future Journal of Pharmaceutical Sciences (Jun 2016)

Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents

  • Nasser S.M. Ismail,
  • Eslam M.H. Ali,
  • Diaa A. Ibrahim,
  • Rabah A.T. Serya,
  • Dalal A. Abou El Ella

DOI
https://doi.org/10.1016/j.fjps.2016.02.002
Journal volume & issue
Vol. 2, no. 1
pp. 20 – 30

Abstract

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Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structure–activity relationships of pyrazolo[3,4-d]pyrimidines reported to date.

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