Digital Gangrene in Association with Retinoblastoma

Abstract

We report a 5-year old boy, diagnosed with Retinoblastoma (RB) in the right eye and subsequently developed digital gangrene as a result of Raynaud’s phenomenon. Color Doppler ultrasound showed occlusion of radial and ulnar arteries of the left upper limb. Antinuclear Antibody, Antiphospholipid Antibody (APLA) and rheumatoid factors were negative. The patient was treated with low molecular weight heparin (enoxaparin), nifedipine, and analgesics. Raynaud’s syndrome and digital gangrene constitute a rare paraneoplastic process, which was not reported with retinoblastoma earlier.

Keywords

• paraneoplastic syndrome
• raynaud’s phenomenon
• color doppler ultrasound