A case of pelvic EWSR1-PATZ1 fusion sarcoma treated with carbon ion radiotherapy

Toshinari Yagi, MD; Osamu Suzuki, PhD; Haruki Matsuoka, MD; Kei Shinyashiki, MD; Toru Wakamatsu, MD, PhD; Hironari Tamiya, MD, PhD; Rie Suzuki, MD; Shigeki Kakunaga, MD, PhD; Satoshi Takenaka, MD, PhD; Yoshiko Hashii, MD, PhD; Ken-ichi Yoshida, MD, PhD; Katsuyuki Nakanishi, MD, PhD

Radiology Case Reports (Jul 2024)

A case of pelvic EWSR1-PATZ1 fusion sarcoma treated with carbon ion radiotherapy

Toshinari Yagi, MD,
Osamu Suzuki, PhD,
Haruki Matsuoka, MD,
Kei Shinyashiki, MD,
Toru Wakamatsu, MD, PhD,
Hironari Tamiya, MD, PhD,
Rie Suzuki, MD,
Shigeki Kakunaga, MD, PhD,
Satoshi Takenaka, MD, PhD,
Yoshiko Hashii, MD, PhD,
Ken-ichi Yoshida, MD, PhD,
Katsuyuki Nakanishi, MD, PhD

Affiliations

Toshinari Yagi, MD: Department of Outpatient Chemotherapy, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan; Corresponding author.
Osamu Suzuki, PhD: Osaka Heavy Ion Therapy Center, 3-1-10 Otemae, Chuo-ku, Osaka 540-0008, Japan
Haruki Matsuoka, MD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Kei Shinyashiki, MD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Toru Wakamatsu, MD, PhD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Hironari Tamiya, MD, PhD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Rie Suzuki, MD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Shigeki Kakunaga, MD, PhD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Satoshi Takenaka, MD, PhD: Department of Orthopedic Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Yoshiko Hashii, MD, PhD: Department of Pediatrics, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Ken-ichi Yoshida, MD, PhD: Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan
Katsuyuki Nakanishi, MD, PhD: Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka 541-8567, Japan

Journal volume & issue: Vol. 19, no. 7
pp. 2674 – 2678

Abstract

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EWSR1-PATZ1 fusion sarcoma is a type of round-cell sarcoma with EWSR1-non-EST fusion that was newly categorized in the 2020 World Health Organization classification of soft tissue and bone tumors. In general, local disease is managed via surgical resection; however, at present, there is no standard therapy for locally advanced or metastatic disease. Here, we report our experience with a middle-aged male patient with pelvic EWSR1-PATZ1 fusion sarcoma who was treated with carbon ion radiotherapy and maintained stable disease for 13 months. The patient's clinical course suggests that carbon ion radiotherapy may be effective in patients with locally advanced EWSR1-PATZ1 fusion sarcoma.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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