Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system

Srujana S. Yadavalli; Jeffrey N. Carey; Rachel S. Leibman; Annie I. Chen; Andrew M. Stern; Manuela Roggiani; Andrew M. Lippa; Mark Goulian

doi:10.1038/ncomms12340

Nature Communications (Jul 2016)

Antimicrobial peptides trigger a division block in Escherichia coli through stimulation of a signalling system

Srujana S. Yadavalli,
Jeffrey N. Carey,
Rachel S. Leibman,
Annie I. Chen,
Andrew M. Stern,
Manuela Roggiani,
Andrew M. Lippa,
Mark Goulian

Affiliations

Srujana S. Yadavalli: Department of Biology, School of Arts and Sciences, University of Pennsylvania
Jeffrey N. Carey: Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania
Rachel S. Leibman: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Annie I. Chen: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Andrew M. Stern: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Manuela Roggiani: Department of Biology, School of Arts and Sciences, University of Pennsylvania
Andrew M. Lippa: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Mark Goulian: Department of Biology, School of Arts and Sciences, University of Pennsylvania

DOI: https://doi.org/10.1038/ncomms12340
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The PhoQ/PhoP system regulates antimicrobial peptide defense in bacteria. Here the authors show that at sublethal concentrations of antimicrobial peptides, PhoPQ induces QueE, that then localizes to the divisome and blocks cell division independently of its function in queuosine biosynthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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