Nature Communications (May 2019)

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

  • Marc Rosenbaum,
  • Andreas Gewies,
  • Konstanze Pechloff,
  • Christoph Heuser,
  • Thomas Engleitner,
  • Torben Gehring,
  • Lara Hartjes,
  • Sabrina Krebs,
  • Daniel Krappmann,
  • Mark Kriegsmann,
  • Wilko Weichert,
  • Roland Rad,
  • Christian Kurts,
  • Jürgen Ruland

DOI
https://doi.org/10.1038/s41467-019-10203-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner.