Impact of Hyperbaric Oxygenation on Blood Anticolibacillary Activity in Hepatectomy

Abstract

Objective: to study the anticolibacillary activity of arterial (aorta) and venous (portal vein, hepatic veins) blood during hepatectomy and hyperbaric oxygenation (HBO).Material and methods: Experiments were conducted on 40 non-inbred female albino rats exposed to hepatic resection (15—20% of organ mass) and HBO at 3 ata for 50 min once daily within the first three days after surgery. The bactericidal action of blood serum against E.coli and the capacity of neutrophils and monocytes to absorb this microbe were investigated.Results: HBO prevents a hepatectomy-induced reduction in serum bactericidal activity in the portal venous blood, but its reduction in arterial blood remains. Along with this, hepatectomy-induced impairment in the capacity of the liver to stimulate the phagocytic activity of neutrophils and monocytes against E.coli is eliminated under HBO. The latter selectively stimulates the rate of venous blood neutrophilic absorption of E.coli, with this property being lowered in monocytes.Conclusion: HBO eliminates the body’s anticolibacillary defense impairments during hepatectomy.

Keywords

• liver
• resection
• hyperoxia
• hepatectomy
• bactericidal activity
• e.coli