A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis

Jasmine Ga May Eng; Mohammadamin Shahsavarani; Daniel Patrick Smith; Josef Hájíček; Vincenzo De Luca; Yang Qu

doi:10.1038/s41467-022-31100-1

Nature Communications (Jun 2022)

A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis

Jasmine Ga May Eng,
Mohammadamin Shahsavarani,
Daniel Patrick Smith,
Josef Hájíček,
Vincenzo De Luca,
Yang Qu

Affiliations

Jasmine Ga May Eng: Department of Chemistry, University of New Brunswick
Mohammadamin Shahsavarani: Department of Chemical Engineering, University of New Brunswick
Daniel Patrick Smith: Department of Chemistry, University of New Brunswick
Josef Hájíček: Department of Chemistry, Charles University in Prague
Vincenzo De Luca: Department of Biological Sciences, Brock University
Yang Qu: Department of Chemistry, University of New Brunswick

DOI: https://doi.org/10.1038/s41467-022-31100-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Catharanthus roseus is the source for anticancer drug vinblastine and other medicinal monoterpenoid indole alkaloids. Here the authors characterize an Fe/2OG dioxygenase, vindolinine synthase, which catalyzes an unusual redox-neutral reaction leading to alkaloid diversity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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