Stroke: Vascular and Interventional Neurology (Nov 2022)

Clinical Outcomes in Basal Ganglia Strokes Treated With Mechanical Thrombectomy

  • Mehdi Bouslama,
  • Diogo C. Haussen,
  • Krishnan Ravindran,
  • Bernardo B. Liberato,
  • Nirav R. Bhatt,
  • Digvijaya Navalkele,
  • Nicolas A. Bianchi,
  • Samir R. Belagaje,
  • Michael R. Frankel,
  • Raul G. Nogueira

DOI
https://doi.org/10.1161/SVIN.122.000350
Journal volume & issue
Vol. 2, no. 6

Abstract

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Background Basal ganglia infarcts are thought to carry worse clinical outcomes compared with other infarct patterns. We aimed to investigate whether pretreatment topographic infarct patterns including complete basal ganglia involvement versus other infarct patterns help predict mechanical thrombectomy outcomes. Methods This was a review of a prospectively collected database of consecutive mechanical thrombectomy patients with anterior circulation large vessel occlusion strokes between January 2014 and November 2018. Patients were categorized into the following 2 groups: (1) total basal ganglia (TBG) strokes defined as infarcts affecting both the caudate and lentiform nuclei regardless of cortical involvement and (2) other infarct patterns. Infarct location was assessed on preprocedure noncontrast computed tomography using an automated software (e‐ASPECTS). Baseline characteristics and outcome measures were compared. Results A total of 1011 patients were analyzed of which 234 (23.12%) had TBG strokes. Patients with TBG strokes were younger (P=0.01); had higher National Institutes of Health Stroke Scale (NIHSS) (P=0.006), lower e‐ASPECTS (P<0.001), and lower systolic blood pressure (P=0.024); and had diabetes less often (P=0.01). Baseline characteristics were otherwise comparable between groups. Involvement of the caudate or lentiform nucleus alone was observed in 237 (30.5%) and 21 (2.7%) patients, respectively, in the other infarct patterns group. No internal capsule involvement was detected in either group. There were no differences in terms of 90‐day functional outcomes whether dichotomized (modified Rankin Scale score≤2: TBG=44.6% versus other=50.1%; P=0.14) or looking at the entire spectrum of the scale (shift analysis; P=0.74). However, TBG strokes had significantly higher rates of any parenchymal hematomas (15.4% versus 8.2%; P=0.001), an association that held true in multivariable analysis (adjusted odds ratio, 2.57 [95% CI, 1.41–4.62]; P=0.002). Conclusions Despite increased rates of hemorrhagic transformation, ganglionic infarcts carry similar functional outcomes after mechanical thrombectomy compared with other stroke patterns.

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