Emerging Infectious Diseases (Mar 2018)

Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia

  • Ekaterina Chernyaeva,
  • Mikhail Rotkevich,
  • Ksenia Krasheninnikova,
  • Andrey Yurchenko,
  • Anna Vyazovaya,
  • Igor Mokrousov,
  • Natalia Solovieva,
  • Viacheslav Zhuravlev,
  • Piotr Yablonsky,
  • Stephen J. O’Brien

DOI
https://doi.org/10.3201/eid2403.170151
Journal volume & issue
Vol. 24, no. 3
pp. 579 – 583

Abstract

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Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance.

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