T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

Thomas Krausgruber; Chris Schiering; Krista Adelmann; Oliver J. Harrison; Agnieszka Chomka; Claire Pearson; Philip P. Ahern; Matthew Shale; Mohamed Oukka; Fiona Powrie

doi:10.1038/ncomms11627

Nature Communications (May 2016)

T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine

Thomas Krausgruber,
Chris Schiering,
Krista Adelmann,
Oliver J. Harrison,
Agnieszka Chomka,
Claire Pearson,
Philip P. Ahern,
Matthew Shale,
Mohamed Oukka,
Fiona Powrie

Affiliations

Thomas Krausgruber: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Chris Schiering: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Krista Adelmann: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Oliver J. Harrison: Sir William Dunn School of Pathology, University of Oxford
Agnieszka Chomka: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Claire Pearson: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Philip P. Ahern: Sir William Dunn School of Pathology, University of Oxford
Matthew Shale: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital
Mohamed Oukka: Center for Immunity and Immunotherapies, Seattle Children’s Research Institute
Fiona Powrie: Experimental Medicine Division, Nuffield Department of Clinical Medicine, Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital

DOI: https://doi.org/10.1038/ncomms11627
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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How transcription factor T-bet and Th17 cells contribute to colitis remains incompletely understood. Here the authors identify T-bet as a negative regulator of IL-23R pathway activation and show that T-bet deficient T cells drive colitogenic Th17 responses dependent on the cytokines IL-17A and IL-22.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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