Clinical, Cosmetic and Investigational Dermatology (Sep 2023)
Chronic Atopic Dermatitis with Eosinophilia Improved by Daesiho-Tang: A Case Report
Abstract
Min-Cheol Park,1,2,* Ju-Hyun Lee,3,* Eun-Jin Seong,4 Dong-Sung Lee,5 Eun-Heui Jo2,6 1Department of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, Iksan, Jeollabuk-do, 54538, Republic of Korea; 2Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea; 3Department of Medical Support, Imsil-Gun Medical Center, Imsil, Jeollabuk-do, 55927, Republic of Korea; 4Seoul Clinic, Hanam, Gyeonggi-do, 12945, Republic of Korea; 5College of Pharmacy, Chosun University, Gwangju, Jeollanam-do, 61452, Republic of Korea; 6Department of Acupuncture and Moxibustion, Wonkwang University Korean Medicine Hospital, Jeonju, Jeollabuk-do, 54887, Republic of Korea*These authors contributed equally to this workCorrespondence: Dong-Sung Lee, College of Pharmacy, Chosun University, 309, Pilmundae-ro, Dong-gu, Gwangju, Jeollanam-do, 61452, Republic of Korea, Tel +82-62-230-6386, Fax +82-62-232-8834, Email [email protected] Eun-Heui Jo, Department of Acupuncture and Moxibustion, Wonkwang University Korean Medicine Hospital, 99, Garyeonsan-ro, Deokjin-gu, Jeonju, Jeollabuk-do, 54887, Republic of Korea, Tel +82-63-270-1022, Fax +82-63-270-1199, Email [email protected]: This study is to report a case of chronic atopic dermatitis (AD) with eosinophilia, which did not respond to conventional therapy and was improved by Daesiho-tang (DSHT).Patients and Methods: The patient visited our clinic with symptoms of atopic dermatitis including skin lesions and pruritus. Based on her symptoms, DSHT was prescribed. At each visit, the Scoring Atopic Dermatitis (SCORAD), Dermatology Life Quality Index (DLQI), and accompanying systemic symptoms (ASS) were measured. Multiple Allergen Simultaneous Test (MAST) was initially performed for 108 allergens and analyzed by Western blotting using an Alternate Scoring Method (ASM) according to the specific IgE concentration. Also, peripheral blood laboratory (Lab) tests were performed three times during the patient’s visit.Results: After taking DSHT, the total SCORAD score improved from 62.9 to 23.5, while the patient’s ASS also improved. The DLQI score improved from 19 to 5. The total number of eosinophils in the peripheral blood, which showed a mild increase, recovered from 17.2% (0.98 x103/μL) to 4.5% (0.24 x103/μL). The total IgE slightly decreased, while AST and ALT were also restored to normal ranges.Conclusion: Based on this case, DSHT is considered a potential alternative treatment for AD.Graphical Abstract: Keywords: case report, atopic dermatitis, eosinophilia, Daesiho-tang
