Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival

Yi-qi Yang; Jian Liang; Xiao-dong Han; Rui-min Tian; Xu-sheng Liu; Wei Mao; Hong-tao Xu; Bo Liu; Peng Xu

Biomedicine & Pharmacotherapy (Jan 2019)

Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival

Yi-qi Yang,
Jian Liang,
Xiao-dong Han,
Rui-min Tian,
Xu-sheng Liu,
Wei Mao,
Hong-tao Xu,
Bo Liu,
Peng Xu

Affiliations

Yi-qi Yang: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China
Jian Liang: Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China
Xiao-dong Han: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China
Rui-min Tian: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China
Xu-sheng Liu: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China
Wei Mao: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China
Hong-tao Xu: Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, P.R. China; Corresponding authors at: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, P.R China.
Bo Liu: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China; Corresponding authors at: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, P.R China.
Peng Xu: The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China; Corresponding authors at: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, P.R China.

Journal volume & issue: Vol. 109
pp. 1932 – 1939

Abstract

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Triptriolide (T11) is a natural diterpene diepoxide that derived from Chinese traditional herb medicine (TCHM) Tripterygium wilfordii Hook.F (TWHF). From a structural point of view, T11 is very similar to triptolide (T9), one of the most effectively compounds in TWHF that have already been systematically investigated in the past decades. However, the basic functions and medicinal properties of T11 have not yet been well investigated mainly due to its low abundance in its plant organ. The present study aimed to investigate the protective effects of T11 on puromycin aminonucleoside (PAN) induced apoptotic mouse podocytes and the underlying mechanism. The results showed that T11 had no significant toxicity in podocytes in high dosage, and showed prominent protective effects on PAN induced podocytes injury. Further studies indicated that T11 might exert its protective effects by inhibiting of apoptosis and restoring of survival in PAN induced podocytes.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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