Myocardial Recovery and the Failing Heart: Medical, Device and Mechanical Methods

Abstract

Background: Cardiac remodeling describes the molecular, cellular, and interstitial changes that cause the ventricle to develop pathologic geometry as heart failure progresses. Reverse remodeling, or the healing of a failing heart, leads to improved mortality and quality of life. Findings: Therapies that lead to reverse remodeling include medications such as β-blockers and angiotensin-converting enzyme inhibitors; cardiac resynchronization therapy with biventricular pacing; and mechanical support with left ventricular assist devices. Conclusions: Further study is needed to better predict which patients will benefit most from these therapies and will then go on to experience reverse remodeling and myocardial recovery.

Keywords

• cardiac remodeling
• congestive heart failure
• left ventricular dysfunction
• myocardial recovery
• reverse remodeling
• ventricular assist devices