Nature Communications (Mar 2021)

Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

  • Daniel Schäfer,
  • Stefan Tomiuk,
  • Laura N. Küster,
  • Wa’el Al Rawashdeh,
  • Janina Henze,
  • German Tischler-Höhle,
  • David J. Agorku,
  • Janina Brauner,
  • Cathrin Linnartz,
  • Dominik Lock,
  • Andrew Kaiser,
  • Christoph Herbel,
  • Dominik Eckardt,
  • Melina Lamorte,
  • Dorothee Lenhard,
  • Julia Schüler,
  • Philipp Ströbel,
  • Jeannine Missbach-Guentner,
  • Diana Pinkert-Leetsch,
  • Frauke Alves,
  • Andreas Bosio,
  • Olaf Hardt

DOI
https://doi.org/10.1038/s41467-021-21774-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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There is an unmet clinical need to identify therapeutic options for the treatment of pancreatic cancer (PDAC). Here the authors present a systematic screening approach for the identification of potential PDAC cell surface target candidates for CAR-T cell based immunotherapy, followed by their functional validation in preclinical models.