Hemostasis system correction in patients with cirrhosis

Abstract

Nature of violations of hemostasis system in cirrhosis is difficult, often unpredictable and concerns all its links. Thus both bleedings and thrombosis are possible. Disease decompensation is accompanied by deeper haemostatic imbalance towards thrombophilia. It is connected with that hepatocytes is the main place of synthesis vitamin K dependent pro- and anticoagulant proteins. Respectively, medical tactics should be directed on correction of pathogenetic mechanisms of haemostatic imbalance. Aim. To estimate influence Vikasolum on pro- and anticoagulant link of hemostasis in patients with cirrhosis. Methods and results. 30 patients with cirrhosis were under supervision. Patients received Vikasolum in dose 1.0 ml of 0.01 % solution intramuscularly 3 times a day within 3-4 days, with shift to oral route – on 1 tablet (0.015) twice a day up to 2 weeks. Estimation of procoagulant unit included determination of the number of platelets, prothrombin index, activated partial thromboplastin time, blood-coagulation factor F VIII, fibrinogen levels, «B» and D-dimer fibrinogen. Anticoagulant system was evaluated with activity of coagulation inhibitor of protein C. It is shown that hemostasis condition is characterised by an imbalance towards hyper coagulation on the ground of normal or hyperactivated blood-coagulation factor F VIII in patients with cirrhosis. At appointment of vikasoli increase levels of a protrombin index and the protein C is noted. Conclusion. Vikasolum intake promotes normalisation of a haemostatic imbalance, vitamin K dependent pro- and antikoagulyant factors synthesis.

Keywords

• Liver Cirrhosis
• Hemostasis
• Vikasolum
• Anticoagulants