Journal of Pharmaceutical Analysis (Jun 2015)
Determination of diclofenac in pharmaceutical preparations by voltammetry and gas chromatography methods
Abstract
Rapid, sensitive and specific methods were developed for the determination of diclofenac in pharmaceutical preparations by linear sweep voltammetry (LSV) and gas chromatography (GC) with mass spectrometry (MS) detection. The linearity was established over the concentration range of 5â35 μg/mL for LSV and 0.25â5 μg/mL for GCâMS method. The intra- and inter-day relative standard deviation (RSD) was less than 4.39% and 4.62% for LSV and GCâMS, respectively. Limits of quantification (LOQ) were determined as 4.8 and 0.15 μg/mL for LSV and GCâMS, respectively. No interference was found from tablet excipients at the selected assay conditions. The methods were applied for the quality control of commercial diclofenac dosage forms to quantify the drug and to check the formulation content uniformity. Keywords: Diclofenac, Sweep voltammetry, Chromatographyâmass spectrometry, Pharmaceutical preparation