All-trans Retinoic Acid–Induced Isolated Myocarditis

Ugur Nadir Karakulak, MD; Elifcan Aladag, MD; Tuncay Hazirolan, MD; Necla Ozer, MD; Haluk Demiroglu, MD; Hakan Goker, MD

JACC: Case Reports (Nov 2020)

All-trans Retinoic Acid–Induced Isolated Myocarditis

Ugur Nadir Karakulak, MD,
Elifcan Aladag, MD,
Tuncay Hazirolan, MD,
Necla Ozer, MD,
Haluk Demiroglu, MD,
Hakan Goker, MD

Affiliations

Ugur Nadir Karakulak, MD: Hacettepe University School of Medicine Department of Cardiology, Ankara, Turkey; Address for correspondence: Dr. Ugur Nadir Karakulak, Hacettepe University School of Medicine Department of Cardiology, Ankara 06100, Turkey.
Elifcan Aladag, MD: Hacettepe University School of Medicine Department of Hematology, Ankara, Turkey
Tuncay Hazirolan, MD: Hacettepe University School of Medicine Department of Radiology, Ankara, Turkey
Necla Ozer, MD: Hacettepe University School of Medicine Department of Cardiology, Ankara, Turkey
Haluk Demiroglu, MD: Hacettepe University School of Medicine Department of Hematology, Ankara, Turkey
Hakan Goker, MD: Hacettepe University School of Medicine Department of Hematology, Ankara, Turkey

Journal volume & issue: Vol. 2, no. 13
pp. 2101 – 2106

Abstract

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All-trans retinoic acid (ATRA) is the mainstay of treatment in patients with acute promyelocytic leukemia. Despite being effective, it can lead to cardiac complications either as a component of ATRA syndrome or an isolated form denominated as ATRA-induced isolated perimyocarditis. We present a case of this complication and review the literature. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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