Microdomain forming proteins in oncogenesis

Uspehi Molekulârnoj Onkologii. 2016;3(3):16-29 DOI 10.17650/2313-805X-2016-3-3-16-29

 

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Journal Title: Uspehi Molekulârnoj Onkologii

ISSN: 2313-805X (Print); 2413-3787 (Online)

Publisher: ABV-press

Society/Institution: N.N. Blokhin Russian Cancer Research Center

LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Country of publisher: Russian Federation

Language of fulltext: Russian

Full-text formats available: PDF

 

AUTHORS

I. B. Zborovskaya (Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, Russia)
S. A. Galetskiy (Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, Russia)
A. V. Komel’kov (Research Institute of Carcinogenesis, N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; 24 Kashirskoye shosse, Moscow, 115478, Russia)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text

Lipid rafts are lateral assembles of cholesterol, sphingomyelin, glicosphingolipids and specific proteins within cell plasma membrane. These microdomains are involved into a number of important cellular processes including membrane rearrangement, protein internalization, signal transduction, entry of viruses into the cell. Some of lipid rafts are stabilized by special microdomain-forming proteins such as caveolins, SPFH domain containing superfamily, tetraspanins, galectins, which maintain integrity of rafts and regulate signal transduction via forming of “signalosomes”. Involvement of the different lipid rafts is necessary in many situations such as binding of growth factors with their receptors, integrin regulation, cytoskeleton and extracellular matrix rearrangements, vesicular transport, etc. However, such classes of microdomain-forming proteins are still considered separately from each other. In this review we tried to perform complex analysis of microdomain-forming proteins in regulation of cancer assotiated processes.