Nature Communications (Apr 2018)

Motion model ultrasound localization microscopy for preclinical and clinical multiparametric tumor characterization

  • Tatjana Opacic,
  • Stefanie Dencks,
  • Benjamin Theek,
  • Marion Piepenbrock,
  • Dimitri Ackermann,
  • Anne Rix,
  • Twan Lammers,
  • Elmar Stickeler,
  • Stefan Delorme,
  • Georg Schmitz,
  • Fabian Kiessling

DOI
https://doi.org/10.1038/s41467-018-03973-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The vascular structure of tumors impacts diagnosis, prognosis and drug response; however, imaging methods to analyse this important feature have been hindered by spatial resolution limitations. Here the authors present a tool called motion model ultrasound localization microscopy to morphologically and functionally characterize fine vascular networks in tumors at super-resolution.