Journal of Inflammation Research (Feb 2023)
The Value of the Monocyte to High-Density Lipoprotein Cholesterol Ratio in Assessing the Severity of Knee Osteoarthritis: A Retrospective Single Center Cohort Study
Abstract
Jun Cao,1,* Lin Hua,2,* Liang Dong,3 Zhouhuan Wu,4 Guohui Xue2 1Department of Biochemistry and Molecular Biology, School of Medicine, Jiujiang University, Jiujiang, People’s Republic of China; 2Department of Clinical Laboratory, Jiujiang NO.1 People’s Hospital, Jiujiang, People’s Republic of China; 3Department of Rheumatology, Jiujiang NO.1 People’s Hospital, Jiujiang, People’s Republic of China; 4Department of Pharmacology, School of Medicine, Jiujiang University, Jiujiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guohui Xue, Email [email protected]: Inflammatory responses and metabolic abnormalities play essential roles in the pathophysiology of osteoarthritis (OA). Our study aimed to evaluate the association between monocyte-to-high density lipoprotein-cholesterol ratio (MHR) and OA and compared it with other systemic inflammatory markers.Methods: This study recruited 323 OA cases and age- and sex-matched 283 control participants during the same period. Demographic, clinical, and imaging data and laboratory indicators were obtained from participants’ records. Systemic inflammatory markers were calculated for both cohorts. The diagnostic effectiveness of each index for distinguishing patients with OA was analyzed using receiver operating characteristic (ROC) curves. Spearman’s method and ordered logistic regression were used to analyze the association between each indicator and Kellgren and Lawrence (KL) grade.Results: MHR was significantly higher (0.38± 0.18 vs 0.25± 0.07, p < 0.0001) in OA patients than healthy controls. MHR had the largest area under the ROC curve for predicting OA. Analysis of ordered logistic regression indicated that MHR was a risk factor for OA radiological severity. Spearman correlation analysis indicated that MHR significantly correlates with the KL grade. Moreover, MHR was significantly higher in early stage patients than in healthy controls.Conclusion: These results suggest that an elevated MHR could reflect knee OA severity and might be a useful marker for diagnosis and monitoring of OA.Keywords: osteoarthritis, disease severity, monocyte to high-density lipoprotein cholesterol ratio, inflammation, biomarker
