Nature Communications (Nov 2016)
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
- Dirk S. Paul,
- Andrew E. Teschendorff,
- Mary A.N. Dang,
- Robert Lowe,
- Mohammed I. Hawa,
- Simone Ecker,
- Huriya Beyan,
- Stephanie Cunningham,
- Alexandra R. Fouts,
- Anita Ramelius,
- Frances Burden,
- Samantha Farrow,
- Sophia Rowlston,
- Karola Rehnstrom,
- Mattia Frontini,
- Kate Downes,
- Stephan Busche,
- Warren A. Cheung,
- Bing Ge,
- Marie-Michelle Simon,
- David Bujold,
- Tony Kwan,
- Guillaume Bourque,
- Avik Datta,
- Ernesto Lowy,
- Laura Clarke,
- Paul Flicek,
- Emanuele Libertini,
- Simon Heath,
- Marta Gut,
- Ivo G Gut,
- Willem H. Ouwehand,
- Tomi Pastinen,
- Nicole Soranzo,
- Sabine E. Hofer,
- Beate Karges,
- Thomas Meissner,
- Bernhard O. Boehm,
- Corrado Cilio,
- Helena Elding Larsson,
- Åke Lernmark,
- Andrea K. Steck,
- Vardhman K. Rakyan,
- Stephan Beck,
- R. David Leslie
Affiliations
- Dirk S. Paul
- Medical Genomics, UCL Cancer Institute, University College London
- Andrew E. Teschendorff
- CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- Mary A.N. Dang
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Robert Lowe
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Mohammed I. Hawa
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Simone Ecker
- Medical Genomics, UCL Cancer Institute, University College London
- Huriya Beyan
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Stephanie Cunningham
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Alexandra R. Fouts
- Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine
- Anita Ramelius
- Department of Clinical Sciences, Lund University, Skåne University Hospital
- Frances Burden
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Samantha Farrow
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Sophia Rowlston
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Karola Rehnstrom
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Mattia Frontini
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Kate Downes
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Stephan Busche
- Department of Human Genetics, McGill University
- Warren A. Cheung
- Department of Human Genetics, McGill University
- Bing Ge
- Department of Human Genetics, McGill University
- Marie-Michelle Simon
- Department of Human Genetics, McGill University
- David Bujold
- Department of Human Genetics, McGill University
- Tony Kwan
- Department of Human Genetics, McGill University
- Guillaume Bourque
- Department of Human Genetics, McGill University
- Avik Datta
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Ernesto Lowy
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Laura Clarke
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Paul Flicek
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Emanuele Libertini
- Medical Genomics, UCL Cancer Institute, University College London
- Simon Heath
- CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST)
- Marta Gut
- CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST)
- Ivo G Gut
- CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST)
- Willem H. Ouwehand
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Tomi Pastinen
- Department of Human Genetics, McGill University
- Nicole Soranzo
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus
- Sabine E. Hofer
- Department of Pediatrics, Medical University of Innsbruck
- Beate Karges
- Division of Endocrinology and Diabetes, RWTH Aachen University
- Thomas Meissner
- German Center for Diabetes Research (DZD)
- Bernhard O. Boehm
- Division of Endocrinology, Department of Internal Medicine I, Ulm University Medical Centre
- Corrado Cilio
- Department of Clinical Sciences, Lund University, Skåne University Hospital
- Helena Elding Larsson
- Department of Clinical Sciences, Lund University, Skåne University Hospital
- Åke Lernmark
- Department of Clinical Sciences, Lund University, Skåne University Hospital
- Andrea K. Steck
- Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine
- Vardhman K. Rakyan
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Stephan Beck
- Medical Genomics, UCL Cancer Institute, University College London
- R. David Leslie
- The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- DOI
- https://doi.org/10.1038/ncomms13555
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle.
