Automated respiratory therapy system based on the ARDSNet protocol with systemic perfusion control

Abstract

A medical expert system of automatic artificial ventilation is set up in a star topology with additional closed-loop hemodynamic control. Arterial blood pressure (MAP) is controlled by noradrenaline (NA) as a controlling variable. The overall patient-in-the-loop expert system can intensively and intelligently perform a long-term treatment based on the Acute Respiratory Distress Syndrome Network (ARDSNet) protocol. Three main goals are actively carried out, namely the stabilization and regulation of oxygenation, plateau pressure and blood pH value. The developed system shows a distinctive experimental result based on a 31.5-kg pig, in order to fulfil the ventilatory goals and to ensure proper systemic perfusion. Hence, this system has enormous potentials to realize a commercial system for individual patient with ARDS.

Keywords

• closed-loop ventilation
• automatic ventilation therapy
• ards
• ardsnet protocol