Nature Communications (Sep 2017)
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk
- Xiao Chang,
- Yan Zhao,
- Cuiping Hou,
- Joseph Glessner,
- Lee McDaniel,
- Maura A. Diamond,
- Kelly Thomas,
- Jin Li,
- Zhi Wei,
- Yichuan Liu,
- Yiran Guo,
- Frank D. Mentch,
- Haijun Qiu,
- Cecilia Kim,
- Perry Evans,
- Zalman Vaksman,
- Sharon J. Diskin,
- Edward F. Attiyeh,
- Patrick Sleiman,
- John M. Maris,
- Hakon Hakonarson
Affiliations
- Xiao Chang
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Yan Zhao
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Cuiping Hou
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Joseph Glessner
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Lee McDaniel
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Maura A. Diamond
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Kelly Thomas
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Jin Li
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Zhi Wei
- Department of Computer Science, New Jersey Institute of Technology
- Yichuan Liu
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Yiran Guo
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Frank D. Mentch
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Haijun Qiu
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Cecilia Kim
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- Perry Evans
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Zalman Vaksman
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Sharon J. Diskin
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Edward F. Attiyeh
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Patrick Sleiman
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- John M. Maris
- Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
- Hakon Hakonarson
- The Center for Applied Genomics, Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/s41467-017-00408-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 7
Abstract
Chromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.
