Nature Communications (2017-09-01)

Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk

  • Xiao Chang,
  • Yan Zhao,
  • Cuiping Hou,
  • Joseph Glessner,
  • Lee McDaniel,
  • Maura A. Diamond,
  • Kelly Thomas,
  • Jin Li,
  • Zhi Wei,
  • Yichuan Liu,
  • Yiran Guo,
  • Frank D. Mentch,
  • Haijun Qiu,
  • Cecilia Kim,
  • Perry Evans,
  • Zalman Vaksman,
  • Sharon J. Diskin,
  • Edward F. Attiyeh,
  • Patrick Sleiman,
  • John M. Maris,
  • Hakon Hakonarson

DOI
https://doi.org/10.1038/s41467-017-00408-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 7

Abstract

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Chromosomal abnormalities such as 11q deletion are associated with poor prognosis in neuroblastoma. Here, the authors perform a genome-wide association study and identify an association between a variant within a Matrix metalloproteinase (MMP) gene member, MMP20, and 11q-deletion subtype neuroblastoma.