Nature Communications (Aug 2022)

Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

  • Leyuan Xu,
  • Jiankan Guo,
  • Dennis G. Moledina,
  • Lloyd G. Cantley

DOI
https://doi.org/10.1038/s41467-022-32634-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Acute kidney injury can lead to chronic kidney disease. Here the authors show that the transition is related to a macrophage-mediated second wave of inflammatory cells that promote late tubule injury, dedifferentiation and fibrosis. Suppressing this second wave reduced tubular loss and kidney atrophy.