Frontiers in Aging Neuroscience (Aug 2024)
Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial
- Angel Toval,
- Patricio Solis-Urra,
- Patricio Solis-Urra,
- Esmée A. Bakker,
- Esmée A. Bakker,
- Lucía Sánchez-Aranda,
- Javier Fernández-Ortega,
- Carlos Prieto,
- Rosa María Alonso-Cuenca,
- Rosa María Alonso-Cuenca,
- Alberto González-García,
- Isabel Martín-Fuentes,
- Beatriz Fernandez-Gamez,
- Marcos Olvera-Rojas,
- Andrea Coca-Pulido,
- Darío Bellón,
- Alessandro Sclafani,
- Javier Sanchez-Martinez,
- Ricardo Rivera-López,
- Norberto Herrera-Gómez,
- Norberto Herrera-Gómez,
- Rafael Peñafiel-Burkhardt,
- Víctor López-Espinosa,
- Sara Corpas-Pérez,
- María Belén García-Ortega,
- Alejandro Vega-Cordoba,
- Emilio J. Barranco-Moreno,
- Francisco J. Morales-Navarro,
- Raúl Nieves,
- Alfredo Caro-Rus,
- Francisco J. Amaro-Gahete,
- Francisco J. Amaro-Gahete,
- Francisco J. Amaro-Gahete,
- Jose Mora-Gonzalez,
- Sol Vidal-Almela,
- Anna Carlén,
- Anna Carlén,
- Jairo H. Migueles,
- Kirk I. Erickson,
- Eduardo Moreno-Escobar,
- Eduardo Moreno-Escobar,
- Rocío García-Orta,
- Rocío García-Orta,
- Irene Esteban-Cornejo,
- Irene Esteban-Cornejo,
- Irene Esteban-Cornejo,
- Francisco B. Ortega,
- Francisco B. Ortega,
- Francisco B. Ortega
Affiliations
- Angel Toval
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Patricio Solis-Urra
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Patricio Solis-Urra
- Faculty of Education and Social Sciences, University Andres Bello, Viña del Mar, Chile
- Esmée A. Bakker
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Esmée A. Bakker
- Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, Netherlands
- Lucía Sánchez-Aranda
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Javier Fernández-Ortega
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Carlos Prieto
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Rosa María Alonso-Cuenca
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Rosa María Alonso-Cuenca
- Cardiology Service, San Cecilio Clinical University Hospital, Granada, Spain
- Alberto González-García
- Department of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain
- Isabel Martín-Fuentes
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Beatriz Fernandez-Gamez
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Marcos Olvera-Rojas
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Andrea Coca-Pulido
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Darío Bellón
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Alessandro Sclafani
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Javier Sanchez-Martinez
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Ricardo Rivera-López
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Norberto Herrera-Gómez
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Norberto Herrera-Gómez
- Cardiology Service, San Cecilio Clinical University Hospital, Granada, Spain
- Rafael Peñafiel-Burkhardt
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Víctor López-Espinosa
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Sara Corpas-Pérez
- Cardiology Service, San Cecilio Clinical University Hospital, Granada, Spain
- María Belén García-Ortega
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Alejandro Vega-Cordoba
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Emilio J. Barranco-Moreno
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Francisco J. Morales-Navarro
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Raúl Nieves
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Alfredo Caro-Rus
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Francisco J. Amaro-Gahete
- Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain
- Francisco J. Amaro-Gahete
- CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
- Francisco J. Amaro-Gahete
- Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
- Jose Mora-Gonzalez
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Sol Vidal-Almela
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Anna Carlén
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Anna Carlén
- 0Department of Clinical Physiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
- Jairo H. Migueles
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Kirk I. Erickson
- 1AdventHealth Research Institute, Neuroscience, Orlando, FL, United States
- Eduardo Moreno-Escobar
- Cardiology Service, San Cecilio Clinical University Hospital, Granada, Spain
- Eduardo Moreno-Escobar
- Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
- Rocío García-Orta
- Cardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain
- Rocío García-Orta
- Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
- Irene Esteban-Cornejo
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Irene Esteban-Cornejo
- CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
- Irene Esteban-Cornejo
- Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
- Francisco B. Ortega
- Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
- Francisco B. Ortega
- CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
- Francisco B. Ortega
- 2Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
- DOI
- https://doi.org/10.3389/fnagi.2024.1437567
- Journal volume & issue
-
Vol. 16
Abstract
IntroductionPatients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms.MethodsThis three-arm, single-blinded RCT will include 90 patients with CAD (50–75 years). Participants will be randomized into: (1) control group—usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior).ConclusionThe HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.Clinical trial registrationClinicalTrials.gov, identifier [NCT06214624].
Keywords
