Factor XI and coagulation. Factor XI inhibitors - antithrombotic perspectives

Abstract

Factor XI is a zymogen with an important role in the coagulation cascade. It is activated by FXII, thrombin and or it can be autoactivated. It has a prothrombotic effect after being activated by thrombin, but also through its antifibrinolytic action, stabilizing the formed clot.

Keywords

• factor xi deficiency
• factor xi inhibitors
• hemostasis
• thrombosis
• new class of anticoagulants
• hemophilia c