Identification of a pocket factor that is critical to Zika virus assembly

Nadia M. DiNunno; Daniel J. Goetschius; Anoop Narayanan; Sydney A. Majowicz; Ibrahim Moustafa; Carol M. Bator; Susan L. Hafenstein; Joyce Jose

doi:10.1038/s41467-020-18747-4

Nature Communications (Oct 2020)

Identification of a pocket factor that is critical to Zika virus assembly

Nadia M. DiNunno,
Daniel J. Goetschius,
Anoop Narayanan,
Sydney A. Majowicz,
Ibrahim Moustafa,
Carol M. Bator,
Susan L. Hafenstein,
Joyce Jose

Affiliations

Nadia M. DiNunno: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Daniel J. Goetschius: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Anoop Narayanan: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Sydney A. Majowicz: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Ibrahim Moustafa: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Carol M. Bator: The Huck Institutes of the Life Sciences, The Pennsylvania State University
Susan L. Hafenstein: Department of Biochemistry and Molecular Biology, The Pennsylvania State University
Joyce Jose: Department of Biochemistry and Molecular Biology, The Pennsylvania State University

DOI: https://doi.org/10.1038/s41467-020-18747-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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Here, the authors provide a 3.4 Å resolution structure of mature Zika virus (ZIKV) and identify two lipid moieties, coordinated by hydrophobic residues of the M and E transmembrane helices and between two helices of E protein, that play an essential role in the ZIKV assembly pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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