Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

Abstract

Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1 (A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia.

Keywords

• hypertension
• renin-angiotensin-aldosterone system (raas)
• genetic variations
• ace i/d
• haplotype