Nature Communications (May 2019)
Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
- Kim-Long Truong,
- Stephan Schlickeiser,
- Katrin Vogt,
- David Boës,
- Katarina Stanko,
- Christine Appelt,
- Mathias Streitz,
- Gerald Grütz,
- Nadja Stobutzki,
- Christian Meisel,
- Christina Iwert,
- Stefan Tomiuk,
- Julia K. Polansky,
- Andreas Pascher,
- Nina Babel,
- Ulrik Stervbo,
- Igor Sauer,
- Undine Gerlach,
- Birgit Sawitzki
Affiliations
- Kim-Long Truong
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Stephan Schlickeiser
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Katrin Vogt
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- David Boës
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Katarina Stanko
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Christine Appelt
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Mathias Streitz
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Gerald Grütz
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Nadja Stobutzki
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Christian Meisel
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Christina Iwert
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- Stefan Tomiuk
- Milteny Biotec GmbH
- Julia K. Polansky
- Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin Berlin
- Andreas Pascher
- Department of Surgery, Charité – Universitätsmedizin Berlin
- Nina Babel
- Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin Berlin
- Ulrik Stervbo
- Medical Clinic I, Marien Hospital Herne, University Clinic of Ruhr-University Bochum
- Igor Sauer
- Department of Surgery, Charité – Universitätsmedizin Berlin
- Undine Gerlach
- Department of Surgery, Charité – Universitätsmedizin Berlin
- Birgit Sawitzki
- Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
- DOI
- https://doi.org/10.1038/s41467-019-10018-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.
