Synthesis , characterization and antimicrobial activity of shiff and mannich bases of uracil derivatives

Abstract

In the present work some Shiff bases (1a,b,c,d)were syuthesized using phenyl alanine with aniline by microwave irradiation. Aseries of mannich base (2a,b,c,d) were prepared by the reaction of (1a,b,c,d) with uracil in the presence of formaldehyde.The newly synthesized compounds were characterized on the basis of elemental analysis,I.R and H1NMR. All the synthesized compounds were tested for their antibacterial activites and antifungal activities.

Keywords

• antimicrobial activity
• shiff
• mannich bases and uracil derivatives