Nature Communications (Apr 2023)
Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals
- Xinyuan Cui,
- Kewei Fan,
- Xianghui Liang,
- Wenjie Gong,
- Wu Chen,
- Biao He,
- Xiaoyuan Chen,
- Hai Wang,
- Xiao Wang,
- Ping Zhang,
- Xingbang Lu,
- Rujian Chen,
- Kaixiong Lin,
- Jiameng Liu,
- Junqiong Zhai,
- Ding Xiang Liu,
- Fen Shan,
- Yuqi Li,
- Rui Ai Chen,
- Huifang Meng,
- Xiaobing Li,
- Shijiang Mi,
- Jianfeng Jiang,
- Niu Zhou,
- Zujin Chen,
- Jie-Jian Zou,
- Deyan Ge,
- Qisen Yang,
- Kai He,
- Tengteng Chen,
- Ya-Jiang Wu,
- Haoran Lu,
- David M. Irwin,
- Xuejuan Shen,
- Yuanjia Hu,
- Xiaoman Lu,
- Chan Ding,
- Yi Guan,
- Changchun Tu,
- Yongyi Shen
Affiliations
- Xinyuan Cui
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Kewei Fan
- Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, College of Life Sciences, Longyan University
- Xianghui Liang
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Wenjie Gong
- State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University
- Wu Chen
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Biao He
- Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- Xiaoyuan Chen
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Hai Wang
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Xiao Wang
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Ping Zhang
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Xingbang Lu
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Rujian Chen
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Kaixiong Lin
- Fujian Meihuashan Institute of South China Tiger Breeding
- Jiameng Liu
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Junqiong Zhai
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Ding Xiang Liu
- Integrative Microbiology Research Centre, South China Agricultural University
- Fen Shan
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Yuqi Li
- Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, College of Life Sciences, Longyan University
- Rui Ai Chen
- Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology
- Huifang Meng
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Xiaobing Li
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Shijiang Mi
- State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University
- Jianfeng Jiang
- State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University
- Niu Zhou
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Zujin Chen
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Jie-Jian Zou
- Guangdong Provincial Wildlife Monitoring and Rescue Center
- Deyan Ge
- Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences
- Qisen Yang
- Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences
- Kai He
- Key Laboratory of Conservation and Application in Biodiversity of South China, School of Life Sciences, Guangzhou University
- Tengteng Chen
- Fujian Meihuashan Institute of South China Tiger Breeding
- Ya-Jiang Wu
- Guangzhou Zoo & Guangzhou Wildlife Research Center
- Haoran Lu
- School of Mathematics, Sun Yat-sen University
- David M. Irwin
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Xuejuan Shen
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Yuanjia Hu
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Xiaoman Lu
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- Chan Ding
- Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science
- Yi Guan
- Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College (SUMC)
- Changchun Tu
- Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- Yongyi Shen
- State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-023-38202-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Abstract Wildlife is reservoir of emerging viruses. Here we identified 27 families of mammalian viruses from 1981 wild animals and 194 zoo animals collected from south China between 2015 and 2022, isolated and characterized the pathogenicity of eight viruses. Bats harbor high diversity of coronaviruses, picornaviruses and astroviruses, and a potentially novel genus of Bornaviridae. In addition to the reported SARSr-CoV-2 and HKU4-CoV-like viruses, picornavirus and respiroviruses also likely circulate between bats and pangolins. Pikas harbor a new clade of Embecovirus and a new genus of arenaviruses. Further, the potential cross-species transmission of RNA viruses (paramyxovirus and astrovirus) and DNA viruses (pseudorabies virus, porcine circovirus 2, porcine circovirus 3 and parvovirus) between wildlife and domestic animals was identified, complicating wildlife protection and the prevention and control of these diseases in domestic animals. This study provides a nuanced view of the frequency of host-jumping events, as well as assessments of zoonotic risk.
