Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues
Abdelaaziz Ouahrouch,
Moha Taourirte,
Joachim W. Engels,
Soumaya Benjelloun,
Hassan B. Lazrek
Affiliations
Abdelaaziz Ouahrouch
Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco
Moha Taourirte
Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Gueliz (FSTG), BP 549, Marrakech 40000, Morocco
Joachim W. Engels
Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, D-60438 Frankfurt am Main, Germany
Soumaya Benjelloun
Viral Hepatitis Laboratory Pasteur Institute Morocco, 1, Place Louis Pasteur, 20360, Casablanca 20001, Morocco
Hassan B. Lazrek
Laboratory of Biomolecular and Medicinal Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Marrakech 40000, Morocco
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.
