PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

Sudhir Kumar; Manish Kumar; Roseleen Ekka; Jeffrey D. Dvorin; Aditya S. Paul; Anil K. Madugundu; Tim Gilberger; Harsha Gowda; Manoj T. Duraisingh; T. S. Keshava Prasad; Pushkar Sharma

doi:10.1038/s41467-017-00053-1

Nature Communications (Jul 2017)

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

Sudhir Kumar,
Manish Kumar,
Roseleen Ekka,
Jeffrey D. Dvorin,
Aditya S. Paul,
Anil K. Madugundu,
Tim Gilberger,
Harsha Gowda,
Manoj T. Duraisingh,
T. S. Keshava Prasad,
Pushkar Sharma

Affiliations

Sudhir Kumar: Eukaryotic Gene Expression laboratory, National Institute of Immunology
Manish Kumar: Institute of Bioinformatics
Roseleen Ekka: Eukaryotic Gene Expression laboratory, National Institute of Immunology
Jeffrey D. Dvorin: Harvard TH Chan School of Public Health, Harvard University
Aditya S. Paul: Harvard TH Chan School of Public Health, Harvard University
Anil K. Madugundu: Institute of Bioinformatics
Tim Gilberger: Bernhard Nocht Institute for Tropical Medicine and Centre for Structural Systems Biology
Harsha Gowda: Institute of Bioinformatics
Manoj T. Duraisingh: Harvard TH Chan School of Public Health, Harvard University
T. S. Keshava Prasad: Institute of Bioinformatics
Pushkar Sharma: Eukaryotic Gene Expression laboratory, National Institute of Immunology

DOI: https://doi.org/10.1038/s41467-017-00053-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Calcium dependent protein kinase 1 (CDPK1) plays an important role in asexual development of Plasmodium falciparum. Using phosphoproteomics and conditional knockdown of CDPK1, the authors here identify CDPK1 substrates and a cross-talk between CDPK1 and PKA, and show the role of CDPK1 in parasite invasion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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