Endothelial dysfunction in multiple sclerosis and management options using alpha-lipoic acid

Abstract

81 patients with definite diagnosis of multiple sclerosis (MS) according to McDonald et all. criteria underwent a comprehensive clinical and neurological examination in 2005 and 2010, and their blood serum was measured for the amount of matrix metalloproteinase-9 (MMP9) and von Willebrand factor antigen (vWf) using ELISA. Von Willebrand factor antigen levels were definitely significantly lower in the group of patients treated with alpha-lipoic acid at the time of the study compared with the group without concomitant ALA therapy. There were no significant differences between the groups of patients by the level of MMP9 in this study. ALA therapy for multiple sclerosis has positive effects associated also with a decrease in cerebral vascular endothelial damage, thus making it pathogenetically substantiated.

Keywords

• рассеянный склероз
• эндотелий
• эндотелиальная дисфункция
• матоэнцефалический барьер
• альфа-липоевая кислота
• multiple sclerosis
• endothelium
• endothelial dysfunction
• blood-brain barrier
• alpha-lipoic acid