Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility

Huiran Lin; Huitong Chen; Ao Lin; Xiaoping Liu; Xiaokai Huang; Jingying Zhou; Li Yuan; Zhenjian Zhuo

doi:10.1002/ped4.12286

Pediatric Investigation (Dec 2021)

Associations between LMO1 gene polymorphisms and central nervous system tumor susceptibility

Huiran Lin,
Huitong Chen,
Ao Lin,
Xiaoping Liu,
Xiaokai Huang,
Jingying Zhou,
Li Yuan,
Zhenjian Zhuo

Affiliations

Huiran Lin: Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China
Huitong Chen: Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China
Ao Lin: Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China
Xiaoping Liu: Department of Hematology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China
Xiaokai Huang: Department of Hematology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou Zhejiang China
Jingying Zhou: Department of Hematology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou Zhejiang China
Li Yuan: Department of Pathology Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China
Zhenjian Zhuo: Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou Guangdong China

DOI: https://doi.org/10.1002/ped4.12286
Journal volume & issue: Vol. 5, no. 4
pp. 281 – 287

Abstract

Read online

ABSTRACT Importance LIM domain only 1 (LMO1) gene polymorphisms were previously found to be implicated in the risk of several cancers. No available studies were performed regarding the predisposing effect of LMO1 gene single nucleotide polymorphisms (SNPs) on central nervous system (CNS) tumor risk. Objective We aimed to determine whether the LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case‐control study with 191 cases and 248 controls in China. Methods The contributions of LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic regression. Results Based on the calculations of odds ratio (OR) and 95% confidence interval (CI), we failed to detect a significant relationship between each LMO1 gene SNP (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and CNS tumor risk, respectively. A negative association was also found in the combined effects on these five SNPs and CNS tumor risk. The stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males (OR: 1.74, 95% CI: 1.01–2.98, P = 0.046). Interpretation We concluded that LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese children. More studies are required to verify this association.

Published in Pediatric Investigation

ISSN: 2096-3726 (Print); 2574-2272 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Medicine: Pediatrics
Website: https://onlinelibrary.wiley.com/journal/25742272

About the journal

Abstract

Keywords