CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

Leonid Andronov; Khalid Ouararhni; Isabelle Stoll; Bruno P. Klaholz; Ali Hamiche

doi:10.1038/s41467-019-12383-3

Nature Communications (Sep 2019)

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1

Leonid Andronov,
Khalid Ouararhni,
Isabelle Stoll,
Bruno P. Klaholz,
Ali Hamiche

Affiliations

Leonid Andronov: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Khalid Ouararhni: Institute of Genetics and of Molecular and Cellular Biology (IGBMC)
Isabelle Stoll: Institute of Genetics and of Molecular and Cellular Biology (IGBMC)
Bruno P. Klaholz: Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg
Ali Hamiche: Institute of Genetics and of Molecular and Cellular Biology (IGBMC)

DOI: https://doi.org/10.1038/s41467-019-12383-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Human centromeric nucleosomes contain the specific CENP-A histone variant, which replaces canonical histone H3 and epigenetically marks the centromeres. Here the authors show that CENP-A nucleosomes form large supramolecular clusters during the G1 phase of the cell cycle which are arranged as rosette-like structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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