The problem of biocompatibility and thrombogenicity in mechanical circulatory assist devices

Abstract

Patients suffering from end-stage congestive heart failure are in the severe category of cardiac patients. For many decades, there has been active development of circulatory assist devices. However, despite significant progress made in this area, the use of such devices is associated with several dangerous complications, one of which is thrombosis. The problem of creating biocompatible materials still remains unresolved. Analyzing the mechanism and risk of this complication allows to determine the ways of solving this problem.

Keywords

• heart failure
• heart transplantation
• circulatory support
• thrombosis
• mechanical circulatory support devices