Nature Communications (Jun 2022)
A proteogenomic signature of age-related macular degeneration in blood
- Valur Emilsson,
- Elias F. Gudmundsson,
- Thorarinn Jonmundsson,
- Brynjolfur G. Jonsson,
- Michael Twarog,
- Valborg Gudmundsdottir,
- Zhiguang Li,
- Nancy Finkel,
- Stephen Poor,
- Xin Liu,
- Robert Esterberg,
- Yiyun Zhang,
- Sandra Jose,
- Chia-Ling Huang,
- Sha-Mei Liao,
- Joseph Loureiro,
- Qin Zhang,
- Cynthia L. Grosskreutz,
- Andrew A. Nguyen,
- Qian Huang,
- Barrett Leehy,
- Rebecca Pitts,
- Thor Aspelund,
- John R. Lamb,
- Fridbert Jonasson,
- Lenore J. Launer,
- Mary Frances Cotch,
- Lori L. Jennings,
- Vilmundur Gudnason,
- Tony E. Walshe
Affiliations
- Valur Emilsson
- Icelandic Heart Association
- Elias F. Gudmundsson
- Icelandic Heart Association
- Thorarinn Jonmundsson
- Icelandic Heart Association
- Brynjolfur G. Jonsson
- Icelandic Heart Association
- Michael Twarog
- Novartis Institutes for Biomedical Research
- Valborg Gudmundsdottir
- Icelandic Heart Association
- Zhiguang Li
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging
- Nancy Finkel
- Novartis Institutes for Biomedical Research
- Stephen Poor
- Novartis Institutes for Biomedical Research
- Xin Liu
- Novartis Institutes for Biomedical Research
- Robert Esterberg
- Novartis Institutes for Biomedical Research
- Yiyun Zhang
- Novartis Institutes for Biomedical Research
- Sandra Jose
- Novartis Institutes for Biomedical Research
- Chia-Ling Huang
- Novartis Institutes for Biomedical Research
- Sha-Mei Liao
- Novartis Institutes for Biomedical Research
- Joseph Loureiro
- Novartis Institutes for Biomedical Research
- Qin Zhang
- Novartis Institutes for Biomedical Research
- Cynthia L. Grosskreutz
- Novartis Institutes for Biomedical Research
- Andrew A. Nguyen
- Novartis Institutes for Biomedical Research
- Qian Huang
- Novartis Institutes for Biomedical Research
- Barrett Leehy
- Novartis Institutes for Biomedical Research
- Rebecca Pitts
- Novartis Institutes for Biomedical Research
- Thor Aspelund
- Icelandic Heart Association
- John R. Lamb
- Novartis Institutes for Biomedical Research
- Fridbert Jonasson
- Faculty of Medicine, University of Iceland
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging
- Mary Frances Cotch
- Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health
- Lori L. Jennings
- Novartis Institutes for Biomedical Research
- Vilmundur Gudnason
- Icelandic Heart Association
- Tony E. Walshe
- Novartis Institutes for Biomedical Research
- DOI
- https://doi.org/10.1038/s41467-022-31085-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Age related macular degeneration is a common cause of visual impairment in the elderly, but the etiology is not fully understood. Here, the authors use genetic data, serum proteomics, and AMD phenotypic data from a large Icelandic cohort to discover proteins altered in, causally related to AMD or signifying progression of advanced AMD.
