International Journal of Nanomedicine (Jan 2024)

Combined Placental Mesenchymal Stem Cells with Guided Nanoparticles Effective Against Diabetic Nephropathy in Mouse Model

  • Wang K,
  • Liu T,
  • Zhang Y,
  • Lv H,
  • Yao H,
  • Zhao Y,
  • Li J,
  • Li X

Journal volume & issue
Vol. Volume 19
pp. 901 – 915

Abstract

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Ke Wang,1,2,* Te Liu,1,* Yucheng Zhang,1 Huiying Lv,1 Hua Yao,1 Ye Zhao,3 Jing Li,1 Xiuying Li1 1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Gynecology and Obstetrics Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 3Dermatological Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiuying Li; Jing Li, Email [email protected]; [email protected]: Diabetic nephropathy (DN) is a prevalent complication of diabetes mellitus and constitutes the primary cause of mortality in affected patients. Previous studies have shown that placental mesenchymal stem cells (PL-MSCs) can alleviate kidney dysfunction in animal models of DN. However, the limited ability of mesenchymal stem cells (MSCs) to home to damaged sites restricts their therapeutic potential. Enhancing the precision of PL-MSCs’ homing to target tissues is therefore vital for the success of cell therapies in treating DN.Methods: We developed Fe3O4 coated polydopamine nanoparticle (NP)-internalized MSCs and evaluated their therapeutic effectiveness in a mouse model of streptozotocin- and high-fat diet-induced DN, using an external magnetic field.Results: Our study confirmed that NPs were effectively internalized into PL-MSCs without compromising their intrinsic stem cell properties. The magnetic targeting of PL-MSCs notably improved their homing to the kidney tissues in mice with DN, resulting in enhanced kidney function compared to the transplantation of PL-MSCs alone. Furthermore, the anti-inflammatory and antifibrotic attributes of PL-MSCs played a role in the recovery of kidney function and structure.Conclusion: These results demonstrate that magnetically targeted therapy using PL-MSCs is a promising approach for treating diabetic nephropathy.Keywords: diabetic nephropathy, magnetic targeting, mesenchymal stem cells, iron oxide nanoparticles

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