Italian Journal of Medicine (May 2024)

Acquired hemophilia A in a case of purple urine bag syndrome

  • Vittoria Gammaldi,
  • Anna Guida,
  • Carolina Bologna,
  • Antonietta De Sena,
  • Marina Lugarà,
  • Claudio De Luca,
  • Fabio Granato Corigliano,
  • Mariavittoria Guerra,
  • Gabriella Oliva,
  • Luca Mocerino,
  • Aquilino Flavio Zarrella,
  • Maria Gabriella Coppola,
  • Vincenzo Nuzzo,
  • Paolo Tirelli,
  • Pasquale Madonna

DOI
https://doi.org/10.4081/itjm.2024.1713
Journal volume & issue
Vol. 18, no. 2

Abstract

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The rare hemorrhagic disorder known as acquired hemophilia A (AHA) is brought on by the spontaneous development of autoantibodies against coagulation factor VIII (FVIII). It may be secondary to autoimmune diseases or cancers, or it may be idiopathic. Less than 10% of cases may have an infection as a secondary cause. We present the case of a 90-year-old anemic woman who was admitted to the hospital. She contracted a urinary tract infection (UTI) while in the hospital, and her urine took on a distinct purple hue. She had poor hemorrhagic manifestations and a prolonged partial thromboplastin time. After ruling out autoimmune and neoplastic causes, we diagnosed AHA as a result of a UTI caused by Enterococcus faecalis.

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